Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
LY2835219
204
CHF
CHF 204.00
In stock
CDX-L0303-M100100 mgCHF 204.00
CDX-L0303-M250250 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | LY2835219 methanesulfonate; Abemaciclib methanesulfonate; Abemaciclib mesylate; Bemaciclib |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H32F2N8 . CH4O3S |
| MW | 602.7 |
| CAS | 1231930-82-7 |
| Purity Chemicals | ≥99% |
| Appearance | Off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml) or water (30mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | NCJPFQPEVDHJAZ-UHFFFAOYSA-N |
| Smiles | CCN(CC1)CCN1CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2.CS(=O)(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
Product References
(1) M.A. Dickson; Clin. Cancer Res. 20, 3379 (2014) | (2) L.M. Gelbert, et al.; Invest. New. Drugs 32, 825 (2014) | (3) S.C. Tate, et al.; Clin. Cancer Res. 20, 3763 (2014)