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Chimerigen
GFRAL (human):Fc (human) (rec.)
520
CHF
CHF 520.00
In stock
CHI-HF-210GFRAL-C100100 µgCHF 520.00
| Product Details | |
|---|---|
| Synonyms | GDNF Family Receptor α-like; Gral; Glial Cellline-derived Neurotrophic Factor Receptor α-like; GFR α-like; C6orf144 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human GFRAL (aa 19-351) is fused to the N-terminus of the Fc region of human IgG1. |
| Crossreactivity | Human |
| Biological Activity |
Measured by its binding ability in a functional ELISA. |
| MW | ~50-100kDa |
| Purity | ≥98% (SDS-PAGE) |
| Endotoxin Content | <1EU/mg purified protein (LAL test; Lonza). |
| Reconstitution | Reconstitute at 100μg/ml in sterile PBS. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Protein Negative Control | |
| Other Product Data |
NCBI reference NP_997293.2: GFRAL (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Human GFR α-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
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