GFRAL (mouse):Fc (mouse) (rec.)

Specifications / Handling

More Information
Product Details
Synonyms	GDNF Family Receptor α-like; Gral; Glial Cellline-derived Neurotrophic Factor Receptor α-like; GFR α-like
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	The extracellular domain of mouse GFRAL (aa 20-349) is fused to the N-terminus of the Fc region of mouse IgG2a.
Crossreactivity	Mouse
Biological Activity	Measured by its binding ability in a functional ELISA.
Purity	≥98% (SDS-PAGE)
Endotoxin Content	<0.06EU/μg purified protein (LAL test; Lonza).
Reconstitution	Reconstitute at 100μg/ml in sterile PBS.
Formulation	Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control	Fc (mouse) IgG2a Control (rec.)
Other Product Data	NCBI reference NP_995316.2: GFRAL (mouse)
Declaration	Manufactured by Chimerigen.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Mouse GFR α-like contains a 330aa extracellular domain. It is expressed on hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.

Call	+41 61 926 6040
Fax	+41 61 926 6049