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Chimerigen
VSIG4 (human):Fc (mouse) (rec.)
430
CHF
CHF 430.00
In stock
CHI-HF-211VSIG4-C100100 µgCHF 430.00
| Product Details | |
|---|---|
| Synonyms | V-set and immunoglobulin domain containing 4; Z39Ig; CRIg |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human VSIG4 (aa 20-283) is fused to the N-terminus of the Fc region of mouse IgG2a. |
| Crossreactivity | Human |
| MW | ~68kDa (SDS-PAGE) |
| Purity | ≥98% (SDS-PAGE) |
| Endotoxin Content | <0.06EU/μg protein (LAL test; Lonza). |
| Reconstitution |
Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Protein Negative Control | |
| Other Product Data |
NCBI reference Q9Y279: VSIG4 (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.
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