IL-1α (human) (rec.) (His)

CHF 225.00
In stock
CHI-HR-20001A-C01010 µgCHF 225.00
CHI-HR-20001A-C05050 µgCHF 630.00
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Product Details
Synonyms Interleukin-1α; IL-1F1; IL-1A
Product Type Protein
Properties
Source/Host E. coli
Sequence

Human IL-1α (aa 113-271) is fused at the C-terminus to a His-tag.

Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Endotoxin Content <1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions.
Formulation Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 100mM NaCl.
Other Product Data

NCBI reference NP_000566.3: IL-1α (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1α and IL-1β. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1α was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1α upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1α is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1α and IL-1β. Although most activators fully rely on the inflammasome for IL-1α secretion, some induce the processing and secretion of IL-1α in an inflammasome-independent manner.

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