HMGB1 (rat) (rec.) (His)

CHF 375.00
In stock
CHI-RR-300HMGB1-C02525 µgCHF 375.00
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Product Details
Synonyms High Mobility Group Protein B1
Product Type Protein
Source/Host E. coli
Sequence Rat HMGB1 (aa 24-215) is fused at the N-terminus to a His-tag.
Crossreactivity Rat
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute in sterile water not less than 100μg/ml, which can then be further diluted in other aqueous solutions.
Formulation Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.
Other Product Data NCBI reference NP_037095.1: HMGB1 (rat)
Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-κB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-κB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
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