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JaICA
8-OHdG Check ELISA Kit
928
CHF
CHF 928.00
In stock
JAI-KOG-200SE1 KitCHF 928.00
Figure 1: Standardcurve
| Product Details | |
|---|---|
| Synonyms | 8-hydroxy-2' -deoxyguanosine |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Specific for 8-OHdG. Has been tested to 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG,8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G). |
| Crossreactivity | All |
| Quantity | 96 wells |
| Range | 0.5 to 200 ng/mL |
| Sample Type | Urine |
| Assay Type | Competitive |
| Detection Type | Colorimetric |
| Other Product Data |
This ELISA Kit is suitable for urine and serum samples from animal and human. However, for human serum, tissue and cultured cells, we recommend 8-OHdG Check ELISA Kit (High Sensitivity) (JAI-KOG-HS10E). Detection Guide for Serum/Plasma Detection Guide for Urine |
| Declaration | Manufactured by JaICA. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Do not freeze. |
| Use/Stability | 12 months after the day of manufacturing. See expiry date on ELISA Kit box. |
| Documents | |
| Manual |
 Download PDF |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
8-hydroxy-2'-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials.
Product References
- Quantitative determination of urinary 8-hydroxydeoxyguanosine (8-OH-dg) by using ELISA: S. Saito, et al.; Res. Commun. Mol. Pathol. Pharmacol. 107, 39 (2000) [Development and assessment of 8-OHdG Check ELISA]
- Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events: Y. Nagayoshi, et al.; Am. J. Cardiol. 95, 514 (2005) [Measurement of 8-OHdG in human urine]
- The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists: J. Morillas-Ruiz, et al.; Eur. J. Appl. Physiol. 95, 543 (2005) [Study about exercise, antioxidant supplements and urinary 8-OHdG]
- Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats: T. Someya, et al.; Pediatr. Nephrol. 20, 1430 (2005) [Effect of antioxidants to 8-OHdG in rat urine]
- Acute encephalopathy with refractory status epilepticus: Bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage: T. Shiihara, et al.; J. Neurol. Sci. 250, 159 (2006) [Measurement of 8-OHdG in human urine, serum and cerebro spinal fluid(CSF)]
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