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RevMab
anti-Podoplanin (gp36), Rabbit Monoclonal (RM449)
459
CHF
CHF 459.00
In stock
REV-31-1341-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human tonsil tissue section using anti-Podoplanin rabbit monoclonal antibody (Clone RM449) at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Gp36 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM449 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human Podoplanin protein. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human podoplanin (Gp36). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q86YL7 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
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