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RevMab
anti-cGMP, Rabbit Monoclonal (RM467)
488
CHF
CHF 488.00
In stock
REV-31-1359-00-C05050 µgCHF 488.00
Figure 1: Competitive ELISA showing the specificity of anti-cGMP (RM467). The 96-well plate was coated with 1 ug/mL of Goat anti-rabbit IgG (50 µl/well). 0.05 µg/ml of anti-cGMP (RM467)(50 µl/well) was added and incubated. After wash and block, cGMP and other cyclic nucleotides or nucleoside phosphates (25 µl/well) were added along with 25 µl/well of 1/5,000 diluted HRP conjugated cGMP. TMB was used to develop the color after incubation and wash.
| Product Details | |
|---|---|
| Synonyms | Cyclic Guanosine Monophosphate |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM467 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | KLH-conjugated cGMP. |
| Application |
ELISA: 0.05µg/ml - 0.5µg/ml |
| Crossreactivity | All |
| Specificity |
RM467 reacts to cGMP (Cyclic Guanosine Monophosphate). No cross-reactivity with other cyclic nucleotide or nucleoside phosphate. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | 1 mg/ml |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | N/A |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
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