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RevMab
anti-cAMP, Rabbit Monoclonal (RM466)
488
CHF
CHF 488.00
In stock
REV-31-1358-00-C05050 µgCHF 488.00
Figure 1: Competitive ELISA showing the specificity of anti-cAMP (RM466). The 96-well plate was coated with 1 ug/mL of Goat anti-rabbit IgG (50 µl/well). 0.05 µg/ml of anti-cAMP (RM466) (50 µl/well) was added and incubated. After wash and block, cAMP and other cyclic nucleotides or nucleoside phosphates (25 µl/well) were added along with 25 µl/well of 1/5,000 diluted HRP conjugated cAMP. TMB was used to develop the color after incubation and wash.
| Product Details | |
|---|---|
| Synonyms | Cyclic Adenosine Monophosphate |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM466 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | KLH-conjugated cAMP. |
| Application |
ELISA: 0.05µg/ml - 0.5µg/ml |
| Crossreactivity | All |
| Specificity |
RM466 reacts to cAMP (Cyclic Adenosine Monophosphate). No cross-reactivity with other cyclic nucleotide or nucleoside phosphate. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | 1 mg/ml |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | N/A |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.
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