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RevMab
anti-BCMA (human), Rabbit Monoclonal (RM526)
As low as
477
CHF
CHF 477.00
In stock
Only %1 left
REV-31-1419-00-R100100 µlCHF 477.00
NEW
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human Hodgkin Lymphoma tissue, stained with anti-BCMA rabbit monoclonal antibody clone RM526 at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | BCMA; B Cell Maturation Protein; Tumor Necrosis Factor Receptor Supefamily Member 17; TNFRSF17 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM526 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human BCMA. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human BCMA. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Accession Number | Q02223 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BCMA (B-cell Maturation Antigen) is a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on mature B cells and plasma cells, where it plays a vital role in B cell survival, maturation and antibody production. BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-κB and JNK. In multiple myeloma and other B cell malignancies, BCMA is often overexpressed, making it an important therapeutic target.
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