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Tivozanib
96
CHF
CHF 96.00
In stock
SYN-1013-M0011 mgCHF 96.00
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SYN-1013-M01010 mgCHF 221.00
SYN-1013-M05050 mgCHF 724.00
SYN-1013-M100100 mgCHF 1'185.00

Product Details | |
---|---|
Synonyms | AV-951 |
Product Type | Chemical |
Properties | |
Formula | C22H19ClN4O5 |
MW | 454.9 |
CAS | 475108-18-0 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: VEGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | SPMVMDHWKHCIDT-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively).
Product References
- Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1, -2, and -3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors: F.A. Eskens, et al.; Clin. Cancer Res. 17, 7156 (2011)