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SynKinase
AZD-7762 hydrochloride
CHF 0.00
In stock
SYN-1017-M0011 mgCHF 114.00
SYN-1017-M0055 mgCHF 142.00
SYN-1017-M01010 mgCHF 227.00
SYN-1017-M05050 mgCHF 695.00
SYN-1017-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | AZD7762 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H19FN4O2S . HCl |
| MW | 362.4 . 36.5 |
| CAS | 1246094-78-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Chk1 | Kinase Group: CAMK | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | WFZBLOIXZRZEDG-YDALLXLXSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. AZD7762 is a specific inhibitor for the CHK1/2 kinases with IC(50) values less than 10. AZD7762 enhances radiation sensitivity and gemcitabine-mediated radiosensitization in pancreatic cancer cells and xenografts and thus is helpful in the treatments of potentially many cancers. In addition, AZD7762 is a chemosensitizer and with gemcitabine and radiation produced a significant delay in the growth of pancreatic tumor xenografts with tolerable toxicity. AZD7762 is being studied as an important link in improving both adjuvant therapy and the treatment of metastatic disease.
Product References
- Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair: M.A. Morgan, et al.; Cancer Res. 70, 4972 (2010)
- Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas: V. Oza, et al.; J. Med. Chem. 55, 5130 (2012)
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