Momelotinib

CHF 114.00
In stock
SYN-1035-M0011 mgCHF 114.00
SYN-1035-M0055 mgCHF 156.00
SYN-1035-M01010 mgCHF 227.00
SYN-1035-M05050 mgCHF 639.00
SYN-1035-M100100 mgCHF 1'171.00
 
More Information
Product Details
Synonyms CYT387; Momelotinib
Product Type Chemical
Properties
Formula C23H22N6O2
MW 414.5
CAS 1056634-68-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key ZVHNDZWQTBEVRY-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM) detected against CDK2/cyclin A, MAPK8 (JNK1), PRKCN (PKD3), PRKD1 (PKCµ), ROCK2, and TBK1 kinase as well.
Product References
  1. Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs): C.J. Burns, et al.; Bioorg. Med. Chem. Lett. 19, 5887 (2009)
  2. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms: J.W. Tyner, et al.; Blood 115, 5232 (2010)
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