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SynKinase
Momelotinib
114
CHF
CHF 114.00
In stock
SYN-1035-M0011 mgCHF 114.00
SYN-1035-M0055 mgCHF 156.00
SYN-1035-M01010 mgCHF 227.00
SYN-1035-M05050 mgCHF 639.00
SYN-1035-M100100 mgCHF 1'171.00
| Product Details | |
|---|---|
| Synonyms | CYT387; Momelotinib |
| Product Type | Chemical |
| Properties | |
| Formula | C23H22N6O2 |
| MW | 414.5 |
| CAS | 1056634-68-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: JAK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM) detected against CDK2/cyclin A, MAPK8 (JNK1), PRKCN (PKD3), PRKD1 (PKCµ), ROCK2, and TBK1 kinase as well.
Product References
- Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs): C.J. Burns, et al.; Bioorg. Med. Chem. Lett. 19, 5887 (2009)
- CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms: J.W. Tyner, et al.; Blood 115, 5232 (2010)