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Product Details
Synonyms AMG706
Product Type Chemical
Formula C22H23N5O
MW 373.5
CAS 453562-69-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: PDGFR | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell factor receptor (c-KIT).
Product References
  1. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts: A. Polverino, et al.; Cancer Res. 66, 8715 (2006)
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