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Motesanib
78
CHF
CHF 78.00
In stock
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Product Details | |
---|---|
Synonyms | AMG706 |
Product Type | Chemical |
Properties | |
Formula | C22H23N5O |
MW | 373.5 |
CAS | 453562-69-1 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: PDGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | RAHBGWKEPAQNFF-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell factor receptor (c-KIT).
Product References
- AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts: A. Polverino, et al.; Cancer Res. 66, 8715 (2006)