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SynKinase
PI103
135
CHF
CHF 135.00
In stock
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| Product Details | |
|---|---|
| Synonyms | PI-103 |
| Product Type | Chemical |
| Properties | |
| Formula | C19H16N4O3 |
| MW | 348.4 |
| CAS | 371935-74-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K - AKT - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | TUVCWJQQGGETHL-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110α-δ with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.
Product References
- A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell 9, 341 (2006)
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