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Product Details
Synonyms SAR-302503
Product Type Chemical
Formula C27H36N6O3S
MW 524.7
CAS 936091-26-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells.
Product References
  1. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera: G. Wernig, et al.; Cancer Cell 13, 311 (2008)
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