TG101348

CHF 72.00
In stock
SYN-1104-M0011 mgCHF 72.00
SYN-1104-M0055 mgCHF 108.00
SYN-1104-M01010 mgCHF 180.00
SYN-1104-M05050 mgCHF 575.00
SYN-1104-M100100 mgCHF 1'113.00
 
More Information
Product Details
Synonyms SAR-302503
Product Type Chemical
Properties
Formula C27H36N6O3S
MW 524.7
CAS 936091-26-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key JOOXLOJCABQBSG-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells.
Product References
  1. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera: G. Wernig, et al.; Cancer Cell 13, 311 (2008)
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