GNE-493

CHF 227.00
In stock
SYN-1115-M0011 mgCHF 227.00
SYN-1115-M0055 mgCHF 461.00
SYN-1115-M01010 mgCHF 646.00
SYN-1115-M05050 mgCHF 1'646.00
SYN-1115-M100100 mgCHF 2'490.00
 
More Information
Product Details
Synonyms GNE493
Product Type Chemical
Properties
Formula C17H20N6O2S
MW 372.4
CAS 1033735-94-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K | Kinase Group: Lipid Kinase | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key LEXMMFPAPDGYGZ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GNE-493 is a potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor for the treatment of cancer.
Product References
  1. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer: D.P. Sutherlin, et al.; J. Med. Chem. 53, 1086 (2010)
  2. Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform: T.P. Heffron, et al.; J. Med. Chem. 54, 7815 (2011)
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