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SynKinase
AMG-25
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SYN-1125-M0011 mgCHF 270.00
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SYN-1125-M05050 mgINQ
SYN-1125-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | AMG25 |
| Product Type | Chemical |
| Properties | |
| Formula | C23H17N5O2 |
| MW | 395.4 |
| CAS | 1003311-62-3 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PDGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | IGFSMGCBFTXTJK-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.
Product References
- Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit: E. Hu, et al.; J. Med. Chem. 51, 3065 (2008)
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