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SynKinase
Brivanib alaninate
CHF 0.00
In stock
SYN-1135-M0011 mgCHF 206.00
SYN-1135-M0055 mgCHF 341.00
SYN-1135-M01010 mgCHF 497.00
SYN-1135-M05050 mgCHF 1'277.00
SYN-1135-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | BMS-582664 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H24FN5O4 |
| MW | 441.5 |
| CAS | 649735-63-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: FGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | LTEJRLHKIYCEOX-OCCSQVGLSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Brivanib inhibits VEGFR-2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM.
Product References
- Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist: M. Ayers, et al.; Cancer Res. 67, 6899 (2007)
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