NVP-BSK805 dihydrochloride

INQ
In stock
SYN-1136-M0011 mgCHF 234.00
SYN-1136-M0055 mgCHF 355.00
SYN-1136-M01010 mgCHF 497.00
SYN-1136-M05050 mgCHF 1'348.00
SYN-1136-M100100 mgINQ
 
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Product Details
Synonyms NVPBSK805
Product Type Chemical
Properties
Formula C27H28F2N6O . 2HCl
MW 490.6 . 72.9
CAS 1092499-93-8 (free base)
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key NUOCAPALWRHKCU-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively.
Product References
  1. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805: F. Baffert, et al.; Mol. Cancer Ther. 9, 1945 (2010)
  2. Effects of Jak2 Type 1 Inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 Mutation-Positive and Bcr-Abl-Positive Cell Lines: F. Ringel, et al.; Acta Haematol. 132, 75 (2014)
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