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SynKinase
CEP-33779
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | CEP33779 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H26N6O2S |
| MW | 462.6 |
| CAS | 1346168-57-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: JAK | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | RFZKSQIFOZZIAQ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CEP-33779 is a highly selective, orally active inhibitor for JAK2 with an IC(50) of 1.8nM in enzyme and 61nM in cell activity. It inhibits JAK3 with an IC(50) of 150nM.
Product References
- A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis: K.L. Stump, et al.; Arthritis Res. Ther. 13, R68 (2011)
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