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MLN0128
INQ
In stock
SYN-1157-M0011 mgCHF 135.00
SYN-1157-M0055 mgCHF 227.00
SYN-1157-M01010 mgCHF 369.00
SYN-1157-M05050 mgCHF 1'320.00
SYN-1157-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | MLN-0128; INK-128 |
| Product Type | Chemical |
| Properties | |
| Formula | C15H15N7O |
| MW | 309.3 |
| CAS | 1224844-38-5 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: MEK - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GYLDXIAOMVERTK-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
Product References
- Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy: C. García-García, et al.; Clin. Cancer Res. 18, 2603 (2012)
- The translational landscape of mTOR signalling steers cancer initiation and metastasis: A.C. Hsieh, et al.; Nature 485, 55 (2012)
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