MLN0128

CHF 114.00
In stock
SYN-1157-M0011 mgCHF 114.00
SYN-1157-M0055 mgCHF 192.00
SYN-1157-M01010 mgCHF 311.00
SYN-1157-M05050 mgCHF 1'113.00
SYN-1157-M100100 mgCHF 1'442.00
 
More Information
Product Details
Synonyms MLN-0128; INK-128
Product Type Chemical
Properties
Formula C15H15N7O
MW 309.3
CAS 1224844-38-5
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: MEK - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GYLDXIAOMVERTK-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
Product References
  1. Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy: C. García-García, et al.; Clin. Cancer Res. 18, 2603 (2012)
  2. The translational landscape of mTOR signalling steers cancer initiation and metastasis: A.C. Hsieh, et al.; Nature 485, 55 (2012)
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