SynKinase

MLN0128

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SYN-1157-M100100 mgINQ

Specifications / Handling

More Information
Product Details
Synonyms	MLN-0128; INK-128
Product Type	Chemical
Properties
Formula	C₁₅H₁₅N₇O
MW	309.3
CAS	1224844-38-5
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: MEK - MEK5 - MEK2 - MEK1 \| Kinase Group: STE \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	GYLDXIAOMVERTK-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).

Product References

Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy: C. García-García, et al.; Clin. Cancer Res. 18, 2603 (2012)
The translational landscape of mTOR signalling steers cancer initiation and metastasis: A.C. Hsieh, et al.; Nature 485, 55 (2012)

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