GLPG0634

CHF 227.00
In stock
SYN-1158-M0011 mgCHF 227.00
SYN-1158-M0055 mgCHF 383.00
SYN-1158-M01010 mgCHF 551.00
SYN-1158-M05050 mgCHF 1'568.00
SYN-1158-M100100 mgCHF 2'568.00
 
More Information
Product Details
Synonyms GLPG-0634; Filgotinib
Product Type Chemical
Properties
Formula C21H23N5O3S
MW 425.5
CAS 1206161-97-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK1 - JAK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key RIJLVEAXPNLDTC-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6.
Product References
  1. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases: L. Van Rompaey, et al.; J. Immunol. 191, 3568 (2013)
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