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SynKinase
GLPG0634
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | GLPG-0634; Filgotinib |
| Product Type | Chemical |
| Properties | |
| Formula | C21H23N5O3S |
| MW | 425.5 |
| CAS | 1206161-97-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: JAK1 - JAK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | RIJLVEAXPNLDTC-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6.
Product References
- Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases: L. Van Rompaey, et al.; J. Immunol. 191, 3568 (2013)
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