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SynKinase
CFI-400437
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula | C29H28N6O2 . 2HCl |
| MW | 492.6 . 72.9 |
| CAS | 1168722-82-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: PLK4 | Kinase Group: Other | Substrate: Serine-Threonine |
| InChi Key | XQZOWXHJNLSRCM-AEZZRCKESA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10μM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
Product References
- The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents: R. Laufer, et al.; J. Med. Chem. 56, 6069 (2013)
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