CFI-400437

CHF 227.00
In stock
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Product Details
Synonyms (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride
Product Type Chemical
Properties
Formula C29H28N6O2 . 2HCl
MW 492.6 . 72.9
CAS 1168722-82-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PLK4 | Kinase Group: Other | Substrate: Serine-Threonine

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Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key XQZOWXHJNLSRCM-AEZZRCKESA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
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Product Specification Sheet
Datasheet Download PDF
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10μM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
Product References
  1. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents: R. Laufer, et al.; J. Med. Chem. 56, 6069 (2013)
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