SynKinase

GSK-F1

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SYN-1220-M0011 mgCHF 170.00

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SYN-1220-M01010 mgCHF 553.00

SYN-1220-M100100 mgINQ

SYN-1220-M05050 mgINQ

Specifications / Handling

More Information
Product Details
Synonyms	5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide; GSKF1
Product Type	Chemical
Properties
Formula	C₂₇H₁₈F₅N₅O₄S
MW	603.5
CAS	1402345-92-9
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: PI4KA \| Kinase Group: PIKK \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	MSRFVAYVUUHQCN-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.

Product-specific References

Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels: N. Bojjireddy, et al.; J. Biol. Chem. 289, 6120 (2014)

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