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SynKinase
MBP146-78
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | 4-[2-(4-Fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl] pyridine |
| Product Type | Chemical |
| Properties | |
| Formula | C21H22FN3 |
| MW | 335.4 |
| CAS | 188343-77-3 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: PKG | Kinase Group: AGC | Substrate: Serine-Threonine |
| InChi Key | RBWNFHXBUDPAIO-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG. MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC50 of <1nm.
Product References
- Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target: A.M. Gurnett, et al.; J. Biol. Chem. 277, 15913 (2002)
- Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase: R.G. Donald, et al.; Eukaryot. Cell 1, 317 (2002)
- A role for coccidian cGMP-dependent protein kinase in motility and invasion: H.I. Wiersma, et al.; Int. J. Parasitol. 34, 369 (2004)
- Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor: C.A. Diaz, et al.; Mol. Biochem. Parasitol. 146, 78 (2006)
- Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase: R.G. Donald, et al.; Mol. Biochem. Parasitol. 149, 86 (2006)
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