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AdipoGen Life Sciences
anti-DLL4 (human), mAb (DL86-3AG)
110
CHF
CHF 110.00
In stock
AG-20A-0080-C05050 µgCHF 110.00
AG-20A-0080-C100100 µgCHF 190.00
Figure 1: Western blot analysis using anti-DLL4 (human), mAb (DL86-3AG) (Prod. No. AG-20A-0080) at 1:2'000 dilution.
1: Human DLL4 Fc-protein.
2: Transfected human DLL4 cell lysate (HEK 293).
3: Mock transfected HEK 293 cell lysates.
4: Human DLL1 Fc-protein.
5: Human DLK1 Fc-protein.
6: Human DNER Fc-protein.
7: Human ACE2 Fc-protein (negative control).
1: Human DLL4 Fc-protein.
2: Transfected human DLL4 cell lysate (HEK 293).
3: Mock transfected HEK 293 cell lysates.
4: Human DLL1 Fc-protein.
5: Human DLK1 Fc-protein.
6: Human DNER Fc-protein.
7: Human ACE2 Fc-protein (negative control).
| Product Details | |
|---|---|
| Synonyms | Delta-like Protein 4; Delta4 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | DL86-3AG |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human DLL4 (extracellular domain). |
| Application |
ELISA: (direct and indirect: 1:2’000-1:5’000) Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS. |
| Crossreactivity | Human |
| Specificity |
Recognizes human DLL4. |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
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