AdipoGen Life Sciences

anti-ANGPTL7 (coiled-coil domain) (human), pAb

As low as CHF 190.00

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AG-25A-0095-C100100 µgCHF 190.00

Figure 1: Western blot analysis using anti-ANGPTL7 (CCD) (human), pAb (Prod. No. AG-25A-0095) at 1:2'000 dilution.
1: Human ANGPTL7 (CCD) (FLAG^®-tagged).
2: Human ANGPTL7 (FLAG^®-tagged).
3: Human ANGPTL7 (FLD) (FLAG^®-tagged).
4: Human ANGPTL2 (CCD) (FLAG^®-tagged).
5: Human ANGPTL3 (CCD) (FLAG^®-tagged).
6: Human ANGPTL4 (CCD) (FLAG^®-tagged).
7: Human ANGPTL5 (CCD) (FLAG^®-tagged).
8: Human ANGPTL6.
9: Human ANGPTL3.

Specifications / Handling

More Information
Product Details
Synonyms	Angiopoietin-like Protein 7; Cornea-derived Transcript 6 Protein
Product Type	Polyclonal Antibody
Properties
Source/Host	Rabbit
Immunogen/Antigen	Coiled-coil domain of recombinant human ANGPTL7.
Application	ELISA: (direct and indirect: 1:2’000-1:5’000) Western Blot: (1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application. Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.
Crossreactivity	Human
Specificity	Recognizes the coiled-coil domain of human ANGPTL7 and the ANGPTL7 full length protein. Weakly cross-reacts with the coiled-coil domains of human ANGPTL2, ANGPTL3, ANGPTL4 and ANGPTL5. Weakly cross-reacts with ANGPTL6 and ANGPTL3 full length protein. Does not cross-react with the fibrinogen like domain of ANGPTL7.
Purity Detail	Protein A-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control	Rabbit IgG
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

ANGPTL7 is expressed in various tissues and regulates angiogenesis. Human ANGPTL7 was characterized as a potent target gene of the WNT/ beta-catenin signaling pathway, and is a pharmacogenomics target in the fields of oncology and regenerative medicine. Overexpression of ANGPTL7 increases collagen expression and might exert a pathogenic role in glaucoma.

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