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AdipoGen Life Sciences
anti-LYVE-1 (human), pAb
345
CHF
CHF 345.00
In stock
AG-25T-0101-C05050 µgCHF 345.00
Figure 1: Immunohistochemical detection of endogenous LYVE-1 in cryo sections of human colon carcinoma using anti-LYVE-1 (human), pAb (Prod. No. AG-25T-0101) (red) and anti-human CD31 pAb (green). A: CD31 only; B: LYVE-1 only; C: CD31/LYVE-1.
| Product Details | |
|---|---|
| Synonyms | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1; CRSBP-1 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human LYVE-1 (aa24-232). |
| Application |
Flow Cytometry: (3-10μg/ml) |
| Crossreactivity | Human |
| Specificity |
Recognizes human LYVE-1. |
| Purity | Antigen affinity purified. |
| Purity Detail | Antigen affinity purified. |
| Formulation | Lyophilized. |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml. |
| Isotype Negative Control | |
| Other Product Data |
UniProt ID Q9Y5Y7: Lyve-1 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Product References
- Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls: C.S. von Kaisenberg, et al.; Mol. Hum. Reprod. 16, 778 (2010)
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