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AdipoGen Life Sciences
anti-LYVE-1, pAb
345
CHF
CHF 345.00
In stock
AG-25T-0103-C05050 µgCHF 345.00
Figure 1: Immunohistochemistry detection of endogenous LYVE-1 in cryo sections of mouse colon carcinoma using anti-LYVE-1, pAb (Prod. No. AG-25T-0103) (red) and anti-mouse CD31 pAb (green).
Figure 2: Immunohistochemistry detection of endogenous LYVE-1 in paraffin-embedded sections of mouse intestine using anti-LYVE-1), pAb (Prod. No. AG-25T-0103) (red staining of lymphatic endothelial intestine cells).
Figure 3: Immunofluorescence detection of endogenous LYVE-1 on rat microvessles using anti-LYVE-1, pAb (Prod. No. AG-25T-0103). Method: Rat cardiac lymphatic microvessels, were labeled with anti-LYVE-1, pAb (Prod. No. AG-25T-0103) (revealed in red), adjacent blood vessels with anti-CD31 pAb (revealed in green) and nuclear stain in blue (left image). Lymphatic microvessels labeled with anti-LYVE-1, pAb (Prod. No. AG-25T-0103) (revealed in red) and nuclear stain in blue (right image). Images were obtained at 10x magnification on a Zeiss fluorescence microscope. Scale bar = 100 µm (upper lane); 20x and 40x magnification, Scale bar = 50 µm (lower lanel).
| Product Details | |
|---|---|
| Synonyms | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1; CRSBP-1 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant mouse soluble LYVE-1 (aa24-228). |
| Application |
ELISA: (1-15μg/ml) |
| Crossreactivity |
Mouse Rat |
| Specificity |
Recognizes mouse and rat LYVE-1. |
| Purity | Antigen affinity purified. |
| Purity Detail | Antigen affinity purified. |
| Formulation | Lyophilized. Contains PBS. |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml. |
| Isotype Negative Control | |
| Other Product Data |
UniProt ID Q8BHC0: Lyve-1 (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Product References
- The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors: U. Fidler, et al.; Am. J. Pathol. 168, 1045 (2006)
- Impact of intravenous/intranasal polyinosinic–polycytidylic acid administration on the mediastinal fat-associated lymphoid clusters and lung tissue in healthy mice: YHA. Elewa, et al.; Ann. Anat. 250, 152158 (2023)
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