AdipoGen Life Sciences

anti-SARS-CoV-2 Spike Protein S1, mAb (rec.) (blocking) (Covi-2) (preservative free)

CHF 370.00
In stock
AG-27B-6006PF-C100100 µgCHF 370.00
More Information
Product Details
Synonyms 2019-nCoV Spike Protein S1
Product Type Recombinant Antibody
Properties
Clone Covi-2
Isotype Human IgG1
Source/Host HEK 293 cells
Immunogen/Antigen Recombinant SARS-CoV-2 Spike Protein S1 receptor binding domain.
Label/Conjugates Preservative Free
Application

ELISA Binding Assay

Functional Application: Blocking

Western Blot: Works only in non-denatured conditions (1/1’000).

Crossreactivity Virus
Specificity

Recognizes and binds to recombinant SARS-CoV-2 Spike Protein S1. It blocks the interaction of SARS-CoV-2 Spike Protein S1 (RBD) to human ACE2. Detects a different epitope as anti-SARS-CoV-2 Spike Protein S1, mAb (rec.) (blocking) (Covi-1) (Prod. No. AG-27B-6005PF).

Purity ≥98% (SDS-PAGE)
Purity Detail Protein A purified.
Endotoxin Content <0.001EU/μg
Concentration 1mg/ml
Formulation Liquid. In PBS.
Isotype Negative Control

Human IgG1 Isotype Control (preservative free)

Other Product Data

Uniprot P0DTC2: SARS-CoV-2 

Accession Number P0DTC2
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many other wild animals. Recently, a new severe acute respiratory syndrome β-coronavirus called SARS-CoV-2 (or 2019-nCoV) has emerged, which causes an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19).

SARS-CoV-2 shares 79.5% sequence identity with SARS-CoV and is 96.2% identical at the genome level to the bat coronavirus BatCoV RaTG133, suggesting it had originated in bats. SARS-CoV-2 contains 4 structural proteins, including Envelope (E), Membrane (M), Nucleocapsid (N) and Spike (S), which is a transmembrane protein, composed of two subunits S1 and S2. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor Angiotensin-Converting Enzyme 2 (ACE2) present at the surface of epithelial cells, causing mainly infection of human respiratory cells.

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