AdipoGen Life Sciences

Fas (human):Fc (human) (rec.)

CHF 300.00

In stock

AG-40B-0082-C05050 µgCHF 300.00

AG-40B-0082-30503 x 50 µgCHF 600.00

More Information
Product Details
Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 6; TNFRSF6; Apo-1 Antigen; CD95
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	The Fc portion of human IgG1 is fused to the C-terminus of human Fas (aa 26-170).
Crossreactivity	Human Mouse
Specificity	Binds human FasL with an ED50 of <5ng/ml. Binds mouse FasL.
Biological Activity	Blocks the binding of FasL to Fas.
MW	~47kDa (SDS-PAGE).
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.01EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water.
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	Uni-Prot link P25445: Fas (human)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

FasL is a cytokine that binds to Fas/TNFRSF6, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T cell mediated apoptosis and in T cell development.

Product References

Decitabine treatment of glioma-initiating cells enhances immune recognition and killing: C. Riccadonna, et al.; PLOS One 11, e0162105 (2016)
CART cells are prone to Fas- and DR5-mediated cell death: B.O. Tschumi, et al.; J. ImmunoTherapy Cancer 6, 71 (2018)

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