AdipoGen Life Sciences

IL-6 (mouse):Fc (human) (rec.)

CHF 95.00
In stock
AG-40B-0108-C01010 µgCHF 95.00
AG-40B-0108-30103 x 10 µgCHF 190.00
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Product Details
Synonyms Interleukin-6; B Cell Hybridoma Growth Factor; Interleukin HP-1
Product Type Protein
Source/Host HEK 293 cells

The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2.

Crossreactivity Mouse
Biological Activity

Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml.

MW 50kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg protein (LAL test; Lonza).
Concentration 0.1 mg /ml after reconstitution
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Protein Negative Control

Fc (human) IgG2 Control (rec.)

Other Product Data

Uniprot link P08505 : IL-6 (mouse)

AfCS Signalling Gateway link A004204: IL-6 (mouse)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Interleukin 6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

Product References
  1. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling: P.P. van Krieken, et al.; Mol. Metab. 54, 101341 (2021)
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