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AdipoGen Life Sciences
IL-6 (mouse):Fc (human) (rec.)
95
CHF
CHF 95.00
In stock
AG-40B-0108-C01010 µgCHF 95.00
AG-40B-0108-30103 x 10 µgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-6; B Cell Hybridoma Growth Factor; Interleukin HP-1 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2. |
| Crossreactivity | Mouse |
| Biological Activity |
Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml. |
| MW | 50kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg protein (LAL test; Lonza). |
| Concentration | 0.1 mg /ml after reconstitution |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
Uniprot link P08505 : IL-6 (mouse) AfCS Signalling Gateway link A004204: IL-6 (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Interleukin 6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.
Product References
- Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling: P.P. van Krieken, et al.; Mol. Metab. 54, 101341 (2021)
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