IL-6R (mouse):Fc (mouse) (rec.)
CHI-MF-11006R-C05050 µgCHF 435.00
|Synonyms||Interleukin-6 Receptor Subunit alpha; IL6RA; CD126|
|Sequence||The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a.|
|Biological Activity||Measured by its binding ability in a functional ELISA.|
|Endotoxin Content||<0.06EU/μg protein (LAL test; Lonza).|
|Reconstitution||Reconstitute at 100μg/ml in sterile PBS.|
|Formulation||Lyophilized from 0.2μm-filtered solution in PBS.|
|Other Product Data||NCBI reference CAA37810.1: IL-6R (mouse)|
|Declaration||Manufactured by Chimerigen.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
Interleukin 6 receptor (IL-6R; CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.