IL-6R (human):Fc (human) (rec.)

CHF 410.00
In stock
CHI-HF-21006R-C05050 µgCHF 410.00
More Information
Product Details
Synonyms CD126; gp80; Interleukin-6 receptor subunit alpha; IL6RA
Product Type Protein
Properties
Source/Host CHO cells
Sequence

The extracellular domain of human IL-6R (aa 20-359) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Human
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.06EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference NP_000556.1: IL-6R (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Interleukin-6 (IL-6) is a multifunctional factor, which exerts its activities through binding to a highaffinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6Rα) and a signal transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for highaffinity binding of IL-6 by the complex. A soluble form of the IL-6Rα has been found in the urine of healthy adult humans.

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