AdipoGen Life Sciences

FGF-1 (human) (rec.)

CHF 120.00
In stock
AG-40B-0137-C01010 µgCHF 120.00
AG-40B-0137-30103 x 10 µgCHF 240.00
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Product Details
Synonyms Fibroblast Growth Factor 1; Acidic Fibroblast Growth Factor; Endothelial Cell Growth Factor; ECGF; Heparin-binding Growth Factor 1; HBGF-1
Product Type Protein
Properties
Source/Host E. coli
Sequence Human FGF-1 (aa 16-155) is untagged.
Crossreactivity Human
MW ~16kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. In PBS containing 0.2 mM DTT.
Other Product Data Uni-Prot link P05230: FGF-1 (human)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Fibroblast growth factors (FGFs) constitute a family of heparin-binding polypeptides involved in the regulation of biological responses such as growth, differentiation and angiogenesis. The biological effects of FGFs are mediated by four structurally related receptor tyrosine kinases denoted FGFR1, FGFR2, FGFR3 and FGFR4. FGF-1 [FGF-acidic; ECGF; HBGF-1] is a powerful mitogen of cells of mesodermal, ectodermal and endodermal origin. FGF-1 association with heparan sulfate is a prerequisite for activation of FGF receptors. FGF-1 plays a role in various stages of development and morphogenesis as well as in angiogenesis and wound healing processes. Recent data indicate a role of FGF-1 in inflammation and obesity. FGF-1 is selectively induced in fat cells by high-fat diet feeding and established the PPARγ-FGF-1 axis as a critical pathway that regulates adipose tissue remodeling.

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