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AdipoGen Life Sciences
IL-36α (aa 6-158) (human) (rec.) (untagged)
215
CHF
CHF 215.00
In stock
AG-40B-0165-C01010 µgCHF 215.00
AG-40B-0165-30103 x 10 µgCHF 430.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-36α; Interleukin-1 Family Member 6; IL-1F6; FIL1ε; Interleukin-1ε; Interleukin-1 Homolog 1; IL-1H1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human IL-36α (aa Lys6-Phe158) is untagged. |
| Crossreactivity | Human |
| MW | ~17kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
Uni-Prot link Q9UHA7: Interleukin-36 α |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36α in the pathogenesis of intestinal inflammation has been reported.
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