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AdipoGen Life Sciences
Tim-4 (mouse):Fc (human) (rec.)
250
CHF
CHF 250.00
In stock
AG-40B-0180-C05050 µgCHF 250.00
AG-40B-0180-30503 x 50 µgCHF 500.00
| Product Details | |
|---|---|
| Synonyms | TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of mouse Tim-4 (aa 23-279) is fused to the N-terminus of the Fc region of human IgG1. |
| Crossreactivity |
Human Mouse |
| Application |
Function: - inhibits stimulated T cell proliferation |
| Biological Activity |
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. |
| MW | ~110kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50µl endotoxin-free water. |
| Accession Number | Q6U7R4 |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link: Tim-4 (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Tim-4 (T cell immunoglobulin and mucin domain-containing protein 4) is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. Tim-4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 is expressed solely on antigen presenting cells (APCs) and is not found on T cells in contrast to TIM1 and TIM3. Tim-4 has a short intracellular domain and lacks an inward signaling motif. Tim-4 plays an important role in the proliferation of T helper type 2 (Th2) cells. Tim-4 binds to phosphatidylserine (PS) on the surface of apoptotic cells in a calcium-dependent manner and mediates phagocytosis of apoptotic cells.
Product References
- Bifurcated Asymmetric Field Flow Fractionation of Nanoparticles in PDMS-Free Microfluidic Devices for Applications in Label-Free Extracellular Vesicle Separation: M. Priedols, et al.; Polymers 15, 789 (2023)
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