AdipoGen Life Sciences

LTβR (mouse):Fc (human) (rec.)

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AG-40B-0274-C05050 µgCHF 200.00

AG-40B-0274-30503 x 50 µgCHF 400.00

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Figure 1: LTβR (mouse):Fc (human) (rec.) (AG-40B-0274) binds to its ligand human LIGHT. Method: LTβR (mouse):Fc (human) (rec.) is coated on an ELISA plate at 2µg/ml overnight at room temperature. LIGHT, Soluble (human) (rec.) (AG-40B-0009) or a control Omentin (human) (rec.) (Prod. No. AG-40B-0042) are added (starting at 8000 ng/ml with a twofold serial dilution) for one hour and then detected using an anti-FLAG-HRP antibody.

Specifications / Handling

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Product Details
Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor
Product Type	Protein
Properties
Source/Host	HEK 293 cells. Produced using animal component-free medium.
Sequence	The extracellular domain of mouse LTbetaR (aa 31-217) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity	Human Mouse
Specificity	Binds to mouse and human LTα1β2 (Lymphotoxin β) and LIGHT (TNFsf14).
MW	~60kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.01EU/μg purified protein (LAL test).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water.
Accession Number	P50284
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	UniProt link P50284: LTbetaR (mouse)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Lymphotoxin β receptor (LTβR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTβR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTβR interacts with two ligands: membrane heterotrimeric lymphotoxin LTα1β2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTβR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTβR also plays a role in the development of lymphoid organs. LTβR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases.

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