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Ancell
anti-LTβR (human), mAb (ANCLTR2/9E2) (R-PE)
455
CHF
CHF 455.00
In stock
ANC-267-050120 testsCHF 455.00
Product Details | |
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Synonyms | Lymphotoxin-β Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3 |
Product Type | Monoclonal Antibody |
Properties | |
Clone | ANCLTR2/9E2 |
Isotype | Mouse IgG1κ |
Immunogen/Antigen | Recombinant Human LT. |
Label/Conjugates | R-PE |
Application |
Flow Cytometry |
Crossreactivity | Human |
Formulation | 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by Ancell Corporation. |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Do not freeze. |
Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
The LTβR activates two different NF-κB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTβR activates the classical NF-κB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1β. However, LTβR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.