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AdipoGen Life Sciences
Kaempferitrin
70
CHF
CHF 70.00
In stock
AG-CN2-0039-M0011 mgCHF 70.00
AG-CN2-0039-M0055 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Lespenefril; Lespedin; BRN 0073958; Kaempferol 3,7-dirhamnoside |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H30O14 |
| MW | 578.5 |
| CAS | 482-38-2 |
| Source/Host Chemicals | Isolated from Calendula officinalis. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in ethanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | PUPKKEQDLNREIM-QNSQPKOQSA-N |
| Smiles | O=C1C2=C(O)C=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C=C2OC(C4=CC=C(O)C=C4)=C1O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cytotoxic and anti-inflammatory compound (weak) [1, 4, 8, 10, 11].
- Antioxidant [2, 5].
- Lipid peroxidation inhibitor [2, 5].
- Free radical scavenger [2, 5].
- Inhibitor of myeloperoxidase activity [2, 5].
- Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats [2, 3].
- Insulinomimetic. Modulates glucose homeostasis [12]. Decreases blood glucose levels and stimulates glucose uptake in muscle [3].
- Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells [6].
- Improves insulin resistance by the activation of the classical insulin transduction pathway [7].
- Increases adiponectin secretion in 3T3-L1 adipocytes [7].
- Antinoniceptive [8].
- May have antidyslipidemic activity [9].
Product References
- Kaempferitrin from the leaves of Hedyotis verticillata and its biological activity: A.S. Hamzah, et al.; Planta Med. 60, 388 (1994)
- Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves: E. de Sousa, et al.; J. Nat. Prod. 67, 829 (2004)
- Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle: A.P. Jorge, et al.; Chem. Biol. Interact. 149, 89 (2004)
- Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages: S.H. Fang, et al.; Bioorg. Med. Chem. 13, 2381 (2005)
- Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors: L.O. Regasini, et al.; Phytochemistry 69, 1739 (2008)
- Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes: C.N. Vishnu Prasad, et al.; BBRC 380, 39 (2009)
- Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes: Y.M. Tzeng, et al.; Eur. J. Pharmacol. 607, 27 (2009)
- Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum: G.O. De Melo, et al.; J. Ethnopharmacol. 124, 228 (2009)
- Antidyslipidemic Activity of Hot-water Extracts from Leaves of Cinnamomum osmophloeum Kaneh: T.Y. Lin, et al.; Phytother. Res. 25, 1317 (2011)
- Lotus corniculatus regulates the inflammation induced by bradykinin in a murine model of pleurisy: D.A. Pereira, et al.; J. Agric. Food Chem. 59, 2291 (2011)
- Kaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties: H.S. Rho, et al.; Molecules 16, 3338 (2011)
- Effects of flavonoids on α-glucosidase activity: potential targets for glucose homeostasis: D.F. Pereira, et al.; Nutrition 27, 1161 (2011)
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