AdipoGen Life Sciences

Sclerotiorin

CHF 110.00
In stock
AG-CN2-0054-MC050.5 mgCHF 110.00
AG-CN2-0054-M0011 mgCHF 180.00
AG-CN2-0054-M0055 mgCHF 720.00
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Product Details
Synonyms (S-(R*,R*-(E,E)))-Sclerotiorin
Product Type Chemical
Properties
Formula

C21H23ClO5

MW 390.9
CAS 549-23-5
Source/Host Chemicals Isolated from fungus Penicillium sp.
Purity Chemicals ≥97% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, ethanol or DMF. Sparingly soluble in aqueous buffers.
Identity Determined by 1H-NMR.
Other Product Data

Solubility in aqueous buffers: Dissolve in DMF and then dilute with the aqueous buffer of choice. Sclerotiorin has a solubility of approx. 0.3mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

InChi Key SWJLTKXURNHVHE-UPWXJBBJSA-N
Smiles CC[C@H](C)\C=C(/C)\C=C\C1=CC2=C(Cl)C(=O)[C@](C)(OC(C)=O)C(=O)C2=CO1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Antibiotic [4, 6, 7].
  • Antibacterial [4, 6, 7] with anticancer activity [8].
  • Weak antagonist of human endothelin receptor A (ETA) and B (ETB) [1].
  • Cholesteryl ester transfer protein (CETP) activity inhibitor [2].
  • Grb2-Shc binding inhibitor [3].
  • Potent aldose reductase inhibitor [4].
  • Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor [5].
  • Antioxidant. Free radical scavenger [5].
  • Antifungal [6, 7].
Product References
  1. Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity: L. Pairet, et al.; J. Antibiot. (Tokyo) 48, 913 (1995)
  2. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones: H. Tomoda, et al.; J. Antibiot. (Tokyo) 52, 160 (1999)
  3. Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753: N. Ji-Youn, et al.; J. Microbiol. Biotechnol. 10, 544 (2000)
  4. Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase: C. Chidananda, et al.; Biotechnol. Lett. 28, 1633 (2006)
  5. Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans: C. Chidananda & A.P. Sattur; J. Agric. Food. Chem. 55, 2879 (2007)
  6. Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma: E. M.F. Lucas, et al.; Braz. J. Microbiol. 38, 785 (2007)
  7. Synthesis and antifungal activity of novel sclerotiorin analogues: L. Lin, et al.; J. Agric. Food Chem. 60, 4480 (2012)
  8. Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata: P. Giridharan, et al.; Indian J. Exp. Biol. 50, 464 (2012)
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