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AdipoGen Life Sciences
Globosuxanthone A
90
CHF
CHF 90.00
In stock
AG-CN2-0174-C250250 µgCHF 90.00
AG-CN2-0174-M0011 mgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | (1R,2R)-1,2,8-Trihydroxy-9-oxo-2,9-dihydro-1H-xanthene-1-carboxylate |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H12O7 |
| MW | 304.3 |
| CAS | 917091-74-8 |
| Source/Host Chemicals | Isolated from fungus (species unknown). |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in ethanol, methanol or DMSO (all 1mg/ml). |
| InChi Key | HEFOWMGZUBJFBY-BMIGLBTASA-N |
| Smiles | OC1=C2C(OC(C=C[C@@H](O)[C@]3(C(OC)=O)O)=C3C2=O)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent anticancer agent. Inhibits cell growth, proliferation and survival of human tumor cells lines in vivo and in vitro.
- Exhibits strong cytotoxicity against a panel of human solid tumor cell lines, disrupting the cell cycle leading to the accumulation of cells in either G2/M or S phase and inducing classic signs of apoptosis.
- Antifungal agent against Candida albicans.
Product References
- A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity: E.M.K.Wijeratne, et al.; Bioorg. Med. Chem. 14, 7917 (2006)
- Absolute Configurations of Globosuxanthone A and Secondary Metabolites from Microdiplodia sp.- A Novel Solid-State CD/TDDFT Approach: H. Hussain, et al.; Eur. J. Org. Chem. 2007, 292 (2007)
- A new dibenz[b,e]oxepine derivative, 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a marine-derived fungus, Beauveria bassiana TPU942; H. Yamazaki, et al.; Mar. Drugs 10, 2691 (2012)
- Dihydroxanthenones from the fermentation product of an endophytic fungus Gliomastix murorum: H.Y. Yang, et al.; J. Asian Nat. Prod. Res. 17, 319 (2015)
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