AdipoGen Life Sciences

NAI-857

CHF 100.00

In stock

AG-CN2-0311-M0011 mgCHF 100.00

AG-CN2-0311-M0055 mgCHF 400.00

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Product Details
Synonyms	Lantibiotic NAI 857
Product Type	Chemical
Properties
Formula	C₈₈H₁₂₄N₂₆O₂₉S₅
MW	2170.4
CAS	1648732-25-5
Source/Host Chemicals	Isolated from Streptomyces sp.
Purity Chemicals	≥85% (HPLC)
Appearance	Beige powder.
Solubility	Soluble in DMSO or water.
Identity	Determined by ¹H-NMR and MS.
Declaration	Manufactured by Naicons Srl.
InChi Key	NFQIPNDWWHYOOB-WTDMGOOYSA-N
Smiles	O=C(NCC(NCC(NCC(N1)=O)=O)=O)C(CC(O)=O)NC([C@@H](CSC[C@@H](C(N[C@@H](CSC2)C(NC3CC4=CNC=N4)=O)=O)NC(CNC([C@H]1CSC[C@@H](C(N[C@@H]2C(O)=O)=O)NC3=O)=O)=O)NC([C@H](NC([C@@H]5CS[C@@H](C)[C@H](C(N6[C@H](C(NCC(N5)=O)=O)CCC6)=O)NC([C@H]7NC([C@H](CC8=CC=C(O)C=C8)NC(C(NC([C@H](C(CC)C)NC([C@H](NC(/C(NC(C(N)C(C)CC)=O)=C/C)=O)CSC7)=O)=O)=C)=O)=O)=O)=O)[C@H](O)C)=O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light. Protect from light when in solution.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Antibacterial class I lantibiotic.
Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis. Interferes with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm less efficient than NAI-107 (AG-CN2-0307).
Active against Streptococcus pyogenes and weak antibacterial activity against other tested Gram-positive pathogens.

Product References

Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities: S.I. Maffioli, et al.; ACS Chem. Biol. 10, 1034 (2015)

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