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AdipoGen Life Sciences
NAI-97 [Planosporicin]
100
CHF
CHF 100.00
In stock
AG-CN2-0312-M0011 mgCHF 100.00
AG-CN2-0312-M0055 mgCHF 400.00
| Product Details | |
|---|---|
| Synonyms | Lantibiotic 97518; Lantibiotic NAI 97 |
| Product Type | Chemical |
| Properties | |
| Formula |
C90H125N27O28S5 |
| MW | 2193.5 |
| CAS | 802917-82-4 |
| Source/Host Chemicals | Isolated from Planomonospora sp. |
| Purity Chemicals | ≥75% (HPLC) |
| Appearance | Beige powder. |
| Solubility | Soluble in DMSO or water. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by Naicons Srl. |
| InChi Key | KGQGDWOXFVFCPE-NLQOOPFKSA-N |
| Smiles | O=C(N[C@H](C(NC(C(N[C@H]1CC2=CNC3=C2C=CC=C3)=O)=C)=O)C(C)C)[C@H](NC(/C(NC(C(N)C(C)CC)=O)=C/C)=O)CSC[C@@H](C(N[C@@H](C(N4[C@H](C(NCC(N5)=O)=O)CCC4)=O)[C@H](C)SC[C@H]5C(N[C@H]([C@H](O)C)C(N[C@@H](C(NC(CCC(O)=O)C(NCC(NCC(NCC(N6)=O)=O)=O)=O)=O)CSC[C@@H](C(N[C@@H](CSC7)C(N[C@@H]8CC9=CNC=N9)=O)=O)NC(CNC([C@H]6CSC[C@@H](C(N[C@@H]7C(O)=O)=O)NC8=O)=O)=O)=O)=O)=O)NC1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
-
Antibacterial class I lantibiotic.
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Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis. Interferes with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm less efficient than NAI-107 (AG-CN2-0307).
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Active against aerobic and anaerobic Gram-positive pathogens, including all antibiotic-resistant strains (e.g. MRSA and VRE) in whole cell and in vitro assays as well as in vivo.
Product References
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A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp: F. Castiglione, et al.; Biochemistry 46, 5884 (2007)
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Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens: F. Castiglione, et al.; Chem. Biol. 15, 22 (2008)
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Structure revision of the lantibiotic 97518: S.I. Maffioli, et al.; J. Nat. Prod. 72, 605 (2009)
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Advancing cell wall inhibitors towards clinical applications: S.I. Maffioli, et al.; J. Ind. Microbiol. Biotechnol. 43, 177 (2016) (Review)
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Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae: A.M. Diagne, et al. PLoS Pathog. 18, e1010458 (2022)
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