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AdipoGen Life Sciences
NAI-802
100
CHF
CHF 100.00
In stock
AG-CN2-0310-M0011 mgCHF 100.00
AG-CN2-0310-M0055 mgCHF 400.00
| Product Details | |
|---|---|
| Synonyms | Lantibiotic NAI 802 |
| Product Type | Chemical |
| Properties | |
| Formula |
C90H141N25O26S4 |
| MW | 2117.5 |
| CAS | 1426209-02-0 |
| Source/Host Chemicals | Isolated from Actinoplanes sp. |
| Purity Chemicals | ≥75% (HPLC) |
| Appearance | Beige powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by Naicons Srl. |
| Other Product Data |
Purity Note: The purity is referred exclusively to the main congener(s), the sample also contains minor related congeners. See: Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains: M. Simone, et al.; J. Antibiot. 66, 73 (2013) |
| InChi Key | QQAUGKIXIZJGEV-HEWAHOAGSA-N |
| Smiles | O=C(N[C@H](C(N[C@@H](CSC[C@@H](NC([C@@H](N)C)=O)C(N[C@](CO)([H])C(NCC1=O)=O)=O)C(N[C@H]2C(N[C@H](C(N[C@@]3([H])C(N[C@]([C@@H](C)CC)([H])C(N[C@@H](CCC(O)=O)C(N[C@@](C(NCC(N[C@@]([C@@H]4C)([H])C(N[C@H](C(N[C@]([C@@H](C)CC)([H])C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CS4=O)=O)C)=O)([H])CS[C@H]3C)=O)=O)C(C)C)=O)=O)=O)([H])CS[C@H]2C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)C(C)C)[C@](N1)([H])CC5=CNC6=CC=CC=C56 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
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Actagardin-related class II lantibiotic.
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Antibacterial with improved activity than actagardine against Staphylococcus spp. and Streptococcus spp.
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Shows significant activity against Gram-positive anaerobic bacteria, such as Clostridium difficile, C. butyricum, C. perfringens and Peptostreptococcus asaccharolyticus.
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Most probably inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis.
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Potential novel antimicrobial agent for the treatment of infections caused by Gram-positive pathogens including resistant strains.
Product References
-
Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains: M. Simone, et al.; J. Antibiot. 66, 73 (2013)
-
Lantibiotics produced by Actinobacteria and their potential applications (a review): K.M. Gomes, et al.; Microbiol. 163, 109 (2017)
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Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae: A.M. Diagne, et al. PLoS Pathog. 18, e1010458 (2022)
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