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AdipoGen Life Sciences
Betulinic acid (>99%)
45
CHF
CHF 45.00
In stock
AG-CN2-0415-M0055 mgCHF 45.00
AG-CN2-0415-M02525 mgCHF 130.00
AG-CN2-0415-M100100 mgCHF 390.00
| Product Details | |
|---|---|
| Synonyms | 3β-Hydroxy-20(29)-lupaene-28-oic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H48O3 |
| MW | 456.7 |
| CAS | 472-15-1 |
| Source/Host Chemicals | Isolated from Platanus acerifolia bark. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| Smiles | [H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anti-HIV compound [1].
- Anticancer compound [2].
- Apoptosis inducer [2].
- Modulator of NF-κB [3,4,8].
- Potent DNA topoisomerase II inhibitor [5].
- Potent proteasome activator [6].
- Antimalarial compound [7].
Product References
- Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids: T. Fujioka, et al.; J. Nat. Prod. 57, 243 (1994)
- Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis: E. Pisha, et al.; Nat. Med. 1, 1046 (1995)
- Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9: Y. Takada & B.B. Aggarwal: J. Immunol. 171, 3278 (2003)
- Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy: H. Kasperczyk, et al.; Oncogene 24, 6945 (2005)
- Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica: S. Wada & R. Tanaka; Chem. Biodivers. 2, 689 (2005)
- Activation and inhibition of the proteasome by betulinic acid and its derivatives: L. Huang, et al.; FEBS Lett. 581, 4955 (2007)
- Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice: M.S. de Sa, et al.; Parasitol. Res. 105, 275 (2009)
- Betulinic acid, a natural compound with potent anticancer effects: F.B. Mullauer, et al.; Anticancer Drugs 21, 215 (2010)
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