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AdipoGen Life Sciences
Gitoxin
120
CHF
CHF 120.00
In stock
AG-CN2-0485-M0055 mgCHF 120.00
AG-CN2-0485-M02525 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | Anhydrogitalin; Bigitalin; Pseudodigitoxin; NSC 95099; BRN0077015 |
| Product Type | Chemical |
| Properties | |
| Formula |
C41H64O14 |
| MW | 780.9 |
| CAS | 4562-36-1 |
| RTECS | LZ0525000 |
| Source/Host Chemicals | Isolated from Digitalis purpurea L. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White powder. |
| Solubility | Soluble in pyridine or DMSO. Sparingly soluble in 100% ethanol or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | LKRDZKPBAOKJBT-CNPIRKNPSA-N |
| Smiles | O[C@@H]1[C@H](O)[C@@H](C)O[C@@H](O[C@H]([C@@H](C)O[C@@H](O[C@H]([C@@H](C)O[C@@H](O[C@H](C[C@@]2([H])CC[C@]3([H])[C@]4([H])CC[C@@]5([C@H]([C@@H](O)C[C@]35O)C(CO6)=CC6=O)C)CC[C@@]24C)C7)[C@H]7O)C8)[C@H]8O)C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cardiac glycoside. Natural metabolite of digitoxin. Starting material for the synthesis of gitoxin derivatives with activity as cardiac glycosides.
- Uncompetitive inhibitor of the Na+/K+ ATPase activity.
- Inhibits growth of selected human cancer cells.
Product References
- Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate: D. Satoh, et al.; Pharm. Bull. 5, 253 (1957)
- Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase: D. Krstic, et al.; J. Enzyme Inhib. Med. Chem. 19, 409 (2004)
- Na+/K+-ATPase: Activity and inhibition: M. Colovic, et al.; Russ. J. Phys. Chem. A. 83, 1602 (2009)
- A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase: F. Cornelius, et al.; J. Biol. Chem. 288, 6602 (2013)
- Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase: L. Moreno Y. Banuls, et al.; Mol. Cancer 12, 33 (2013)
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