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AdipoGen Life Sciences
Macrosporin
190
CHF
CHF 190.00
In stock
AG-CN2-0497-M0011 mgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | 1,7-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H12O5 |
| MW | 284.3 |
| CAS | 22225-67-8 |
| Source/Host Chemicals | Isolated from Stemphylium sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow to light orange solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | FKTPLNFTYJEAAB-UHFFFAOYSA-N |
| Smiles | OC1=CC2=C(C(C(C=C(OC)C=C3O)=C3C2=O)=O)C=C1C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anthraquinone antibiotic. Moderate antibacterial agent.
- Photosensitizer (through ROS production) and leaf necrosis inducer.
- Antiproliferative. Moderate cytotoxic in selected cancer cells.
- Shown to inhibit several protein kinases, including Aurora B and FLT3 in low µM range.
- Mycotoxin. Useful as a reference in food analysis.
Product References
- Studies on the metabolic products of Macrosporium porri Elliott Part IV. Structure of Macrosporin (Group III): R. Suemitsu, et al.; Agr. Biol. Chem. 25, 100 (1961)
- Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Hoeller, et al.; J. Nat. Prod. 65, 876 (2002)
- Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium: A. Debbab, et al.; J. Nat. Prod. 72, 626 (2009)
- Protein kinase inhibitors and other cytotoxic metabolites from the fungal endophyte Stemphylium botryosum isolated from Chenopodium album: A.H. Aly, et al.; Mycosphere - J. Fungal Biol. 1, 153 (2010)
- The role of macrosporin in necrotic spots: A. Trigos, et al.; Phytochem. Lett. 4, 122 (2011)
- Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. Fungus: C.-J. Zheng, et al.; J. Nat. Prod. 75, 189 (2012)
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